Role of Carnitine Shuttle System in the Active Transport of Fatty Acyl Coa into the mitochondrial Carnitine Metabolism and Its Role in Fatty Acid Oxidation Creative Proteomics Frontiers Carnitine Traffic in Cells. Link With Cancer Carnitine transport and fatty acid oxidation ScienceDirect Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine